Chaos Inoculation

Chaos Inoculation (often referred to as CI) is a keystone passive skill that grants immunity to chaos damage, but sets maximum life to 1.

Although the character must survive entirely on energy shield instead of life, immunity to chaos damage can be a significant advantage.

Interactions
The chance and duration of both being stunned and receiving an elemental status ailments is based on your base life before CI takes effect. Maximum Life modifiers such as, , etc. apply to the life before CI is applied. Since this base life value is then overwritten by CI, the only advantage life modifiers provide to a CI character is the reduction on stun and status ailment.

Chaos Inoculation no longer grants immunity degeneration effect of while retaining other benefits of the skill as of 2.0.0 with the Blood Rage degeneration damage type changing to physical.

Low life conditions will never trigger while CI is enabled. Effects such as Pain Attunement and On Low Life mods on gear will not activate. For these effects, you must have 50% or less of your current maximum life. Chaos Inoculation sets your maximum life to 1.

Full life conditions will always trigger because you are always at 100% of 1 life.

Interaction with life reduction
Life reductions apply before CI which resets life to 1. For example from.

Blood magic
When linked with, affected skills cannot be cast, even if it is an aura which would drain a relative amount of mana/health.

Chaos resistance reduction/penetration
Since CI grants a flat-out immunity to chaos damage, effects that reduce or penetrate chaos resistance (i.e. Occultist's Void Beacon) have no effect against CI.

CI builds
It is generally best to wait until you have high energy shield before taking CI because it's much easier to survive on life at lower levels. Don't be afraid to take life passive skills for survivability while leveling up, since you can remove them later.

Characters with CI are usually more susceptible to stun and status ailments because of their low base life. Rather than taking otherwise useless life nodes as described above, Stun can be mitigated by increasing the Stun Recovery stat with items and passives or unique items such as, , and. Status ailments can be reduced with high elemental resistances, Elementalist's Elemancer perk with at least 3 golems, or unique items such as or.

Chaos Inoculation works well with some other keystone passives, such as:
 * Ghost Reaver converts life gained from life leech into energy shield. Vaal Pact only disables any regeneration granted from passives that's converted by Zealot's Oath as of 3.0.0
 * Zealot's Oath applies life regeneration to energy shield. Regen effects that are based on maximum life become based on maximum ES. Note that "regeneration" does not include life flasks, as they are just "Recovery".

Location
Chaos Inoculation is located on the northeast edge of the skill tree.

Version history

 * The in-game Character Screen (original patch note wording: Character Sheet) now displays "Immune to Chaos Damage" if you have the Chaos Inoculation keystone passive skill allocated.


 * (Not in patch note) Now does not change the displayed chaos resistance to 100%.


 * Vaal Pact now only applies to leeched life.
 * The passive skills behind Chaos Inoculation have been removed.


 * Fixed an issue where players' life totals could get out of sync when they died from degeneration damage with Chaos Inoculation allocated.


 * Chaos Inoculation now grants no additional energy shield bonus. Its complete immunity to chaos damage, synergy with Blood Rage and other skill combos are deemed sufficient upside to counteract the life penalty.


 * The Chaos Inoculation keystone passive skill now grants +50% Energy Shield rather than +80%.


 * Fixed the interaction between Chaos Inoculation and Blood Magic so that there's no crazy bugged death state any more. If you try to reserve life or mana when you have both of these keystones, you will now die properly.


 * Changed the Chaos Inoculation keystone so that your "real" life value is still used for checks related to stun and elemental status ailments. This will mean that you don't receive giant stuns/chills due to being reduced to 1 life.


 * Chaos Inoculation now grants a multiplicative increase to Energy Shield.


 * Chaos Inoculation now grants +80% energy shield rather than +20%


 * Added 12 Keystone Passives.
 * Chaos Innoculation: 20% increased maximum energy shield. Provides immunity to chaos damage. Maximum life becomes 1.
 * }