不同职业之间的主要区别是他们在天赋树中的起始点不同，一共有6个不同的职业。
所有职业的初始点数相同，升级之后的效果也相同：
- 50生命, +6 每等级
- 40法力, +4 每等级
- 50闪避, +3 每等级 (包括1级)
Players can use any items or skills, providing they have enough of the relevant attribute requirements. Path of Exile allows players the flexibility to dabble in unusual attributes in order to use off-class skills and items. However, it is generally more efficient for players to invest in the attributes appropriate to their character class.
Strength[ | ]
Strength confers raw brute power, and is represented on weapons by high base damage. Strength armor pieces grant physical damage reduction. Monsters aligned with Strength generally hit hard and take many blows to defeat. The element aligned with Strength is Fire. The announced Strength character class is the Marauder.
The Marauder starts off with the following attributes:
- 30 STR
- 14 DEX
- 14 INT
Dexterity[ | ]
Dexterity confers agility in combat, and is represented on weapons by faster attack speeds. Dexterity armor pieces grant the ability to evade enemy blows more often. Monsters aligned with Dexterity are nimble and difficult to hit, often attacking from a distance or with multiple weapons. The element aligned with Dexterity is Ice. The announced Dexterity character class is the Ranger.
The Ranger starts off with the following attributes:
- 14 STR
- 30 DEX
- 14 INT
Intelligence[ | ]
Intelligence confers knowledge – of both arcane magic and deadly combat techniques. It is represented on weapons through improved critical strikes. Intelligence armor pieces grant the wearer a mystical energy shield which protects them from blows and can recharge when they are out of combat. Monsters aligned with intelligence are often weak spell-casters who can be dangerous if not immediately dealt with. The element aligned with Intelligence is Lightning. The announced Intelligence character class is the Witch.
The Witch starts off with the following attributes:
- 14 STR,
- 14 DEX
- 30 INT
Hybrid Characters[ | ]
There are three playable “hybrid” character classes in Path of Exile, which are the Duelist, Templar and Shadow.
Strength/Dexterity[ | ]
The Duelist is a hybrid character class that excels at both Strength and Dexterity skills.
The Duelist starts off with the following attributes:
- 22 STR
- 22 DEX
- 14 INT
Intelligence/Strength[ | ]
The Templar is aligned with both Strength and Intelligence.
The Templar starts off with the following attributes:
- 22 STR
- 14 DEX
- 22 INT
Intelligence/Dexterity[ | ]
The Shadow is a aligned with Dexterity and Intelligence skills.
The Shadow starts off with the following attributes:
- 14 STR
- 22 DEX
- 22 INT
Other[ | ]
Characters, monsters and items can also be aligned with multiple attributes at once. For example, a staff weapon is generally about 70% strength and 30% intelligence. It differs from a maul (which could be 100% strength) because it is better at scoring critical strikes, but doesn't hit for as much raw physical damage.